CISPLATIN AND PROGESTERONE SEPARATE AND JOINT ACTION ON RAT THYMUS NUCLEAR PHOSPHOLIPIDS COMPOSITION AND CONTENT

The antitumor agent cisplatin and progesterone separate joint action on content of total phospholipids their individual fractions in nuclei from rat thymus cells were investigated. When used separately, exhibit its own distinctive properties. Cisplatin reduces, progesterone, the contrary, increases phospholipids. together, effects these drugs are summed up. Thus phospholipid cell by 17% after injection progesterone. These changes have different quantities fractions. It is assumed that both action, can be mediated quantitative internuclear lipids turn regulate main functions nuclei.